Chronic knee pain is not just a “wear and tear” problem. It is an active biological process. At the Madras Rejuvenation Centre, our approach begins by helping patients understand why inflammation switches on, why it fails to switch off, and how this disrupts the knee’s natural healing environment.
Your two foundational videos—the Start Here introduction and the Inflammation video—establish the scientific framework for this different way of thinking about knee arthritis.
This article integrates the key concepts from both, giving readers a clear, structured overview of why their knees hurt and how modern biologic medicine now addresses the root mechanisms behind their symptoms.
1. The Real Cause of Knee Arthritis: Failed Inflammatory Resolution
In your Inflammation video, you explain that knee osteoarthritis is not simply a degenerative process. Instead, it represents a state in which inflammation turns on correctly—but fails to resolve.
Inflammation begins for a reason. Even minor stress, micro-injury, or low-grade metabolic imbalance can trigger it. The problem is not the trigger. The problem is the body’s inability to complete the “resolution phase.”
When this resolution fails:
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Joint lining stays irritated
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Cartilage remains vulnerable
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Pain sensors keep firing
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Synovial fluid becomes less protective
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Healing switches off
This framework shifts the conversation away from “old age” and toward modifiable biology.
2. Why Inflammation Fails to Switch Off
The Start Here video underscores that modern knee arthritis care must begin with understanding these control mechanisms, not merely suppressing pain.
Here is what we now know:
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Chronic inflammation is orchestrated, not chaotic.
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It involves specific molecules, signals, mediators, and checkpoints.
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When these checkpoints malfunction, the inflammatory programme gets stuck.
Your upcoming sequel videos (Alarmins → Metabolic OA → Biologics → PRASAD) expand on these individual checkpoints.
3. The Two Core Questions Every Patient Must Understand
Your Start Here video frames the patient journey with two essential questions:
Question 1: What keeps turning inflammation on?
This relates to mechanical triggers, metabolic stress, tissue strain, and danger signals inside the joint.
Question 2: Why does inflammation fail to turn off?
This includes disrupted resolution pathways, biochemical imbalances, and molecular “stop signals” that fail.
The Inflammation video gives patients the foundation to explore these deeper mechanisms in a structured, stepwise manner.
4. Why This Matters for Patients
Most patients have only been offered:
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Painkillers
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Steroid injections
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Taping or braces
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General exercise prescriptions
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Advice to “lose weight”
But none of this fixes why the joint environment remains inflamed.
Your channel and clinic offer something different: a biologic first approach that restores the natural regulatory system inside the joint—rather than suppressing it artificially.
This empowers patients by:
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Giving a clear scientific roadmap
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Explaining the sequence from inflammation → damage → worsening
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Showing how intervention can be targeted at each checkpoint
Your Start Here video serves as the front door to this roadmap.
5. The MJRC Approach: A Sequential Educational Pathway
Your pillar sequence is designed to build a coherent narrative:
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Wear & Tear (myth-busting)
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Exercise (benefits and limitations)
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Inflammation (foundation)
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Start Here (orientation)
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Alarmins (danger signals)
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Metabolic OA (system-level factors)
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Biologic Interventions (restorative tools)
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PRASAD (your flagship protocol)
This blog post links your first two steps so patients begin with a correct understanding before accessing deeper content.
6. Watch the Videos for a Clear Starting Point
Start Here Video (Version 1)
Your essential orientation video that outlines the entire philosophy of knee arthritis care at the Madras Rejuvenation Centre.
The Inflammation Video
A foundational explanation of why knee pain persists and what controls the switch of inflammation inside the joint.
These provide the intellectual foundation for patients before entering the more advanced checkpoint videos.
7. What Comes Next
This integrated understanding prepares viewers for your next release:
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The Alarmins video: the molecules that keep inflammation switched on
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Followed by Metabolic OA, Biologics, and PRASAD treatment
Any patient entering your ecosystem with this two-video primer will now understand:
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Why knee arthritis is a biological disorder
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Why it progresses
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Why conventional treatments often fail
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Why your system focuses on resolution instead of suppression