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Platelet-rich stroma treatment knee arthritis Chennai
This gentleman sought Platelet-rich stroma treatment knee arthritis Chennai from Dr.A.K.Venkatchalam. Although he had advanced grade 4 arthritis in both knees, the treatment provided pain relief after 3 days.
Osteoarthritis (OA) of the knee, a condition where the protective cartilage wears away, can be a source of chronic pain and limit mobility. While traditional treatments like medication and physical therapy offer relief, they don’t address the root cause. Enter platelet-rich stroma (PRS) treatment, a promising new approach that harnesses the body’s own healing potential.
What is Platelet-rich stroma treatment knee arthritis Chennai (PRS)?
PRS is a minimally invasive procedure that combines two powerful components:
- Platelet-rich plasma (PRP): Concentrated platelets from your blood, rich in growth factors that promote tissue repair and regeneration.
- Stromal vascular fraction (SVF): A collection of stem cells and other healing cells derived from your fat tissue.
How does PRS work for knee OA?
When injected into the knee joint, PRS delivers a concentrated dose of healing factors:
- Reduced inflammation: SVF’s stem cells have anti-inflammatory properties, calming the pain and joint damage.
- Cartilage regeneration: Growth factors in PRP stimulate cartilage growth and repair damaged tissue.
- Improved lubrication: PRS promotes the production of synovial fluid, the lubricant that keeps your joints moving smoothly.
Benefits of PRS for knee OA:
- Pain relief: Studies show significant pain reduction after PRS treatment, improving quality of life.
- Improved function: Patients experience increased mobility and flexibility, allowing for better daily activities.
- Potential to delay surgery: PRS may offer a non-surgical option for managing OA, potentially postponing or even avoiding joint replacement.
- Minimally invasive: The procedure is relatively quick and well-tolerated, with minimal downtime. experienced in PRS therapy to discuss if it’s right for you.
- Conclusion:
Platelet-rich stroma therapy is a cutting-edge treatment for knee osteoarthritis that utilizes the patient’s adipose (fat) tissue and Platelet-rich plasma (PRP) to promote healing and reduce pain.
It is done as an outpatient procedure and takes about 2 hours as stated by this patient. He went home soon after and was able to walk without any pain using minimal support.
Plaelet-rich stroma treatment is a safer alternative to knee replacement as said by this patient.
If you want to see more testimonials about biologic treatments for knee arthritis, and shoulder problems, visit Testimonials | Ortho Biologic Surgery Indiahttps://orthobiologicsurgeryindia.com/testimonials-stem-cell-treatment-knee-arthritis/
Stem cell treatment knee arthritis Chennai
Stem cell treatment knee arthritis Chennai. See this patient’s testimonial
Fat-derived stem cell treatment for knee osteoarthritis is a relatively new and promising therapy that is being investigated as a potential way to regenerate damaged cartilage and alleviate pain.
What are stem cells?
Stem cells are undifferentiated cells that have the ability to divide and give rise to specialized cells. They can be found in various parts of the body, including bone marrow, adipose tissue (fat), and umbilical cord blood. Adipose-derived stem cells (ADSCs) are particularly attractive for stem cell therapy because they are relatively easy to harvest and have the potential to differentiate into multiple cell types, including cartilage cells.
How does fat-derived stem cell treatment for knee osteoarthritis work?
The fat-derived stem cells are harvested from the patient’s own body, typically from the abdomen or thigh. The cells are then processed and concentrated in a laboratory. The concentrated stem cells are then injected into the knee joint. Once injected into the knee, the stem cells are believed to have several potential therapeutic effects: Reduce inflammation: Stem cells release anti-inflammatory factors that can help to reduce pain and swelling. Promote cartilage repair: Stem cells may differentiate into cartilage cells and help to repair damaged cartilage. Improve lubrication: Stem cells may help to produce synovial fluid, which lubricates the joint.
What is the evidence for fat-derived stem cell treatment for knee osteoarthritis?
There is growing evidence that fat-derived stem cell treatment is safe and effective for knee osteoarthritis. However, more research is needed to determine the long-term efficacy of this treatment. A 2021 study published in the journal Stem Cell Research & Therapy found that intra-articular injection of ADSCs was safe and effective in reducing pain and improving function in patients with knee osteoarthritis. A 2020 study published in the journal Knee Surgery, Sports Traumatology, Arthroscopy found that intra-articular injection of ADSCs with or without platelet-rich plasma was effective in decreasing pain and symptoms in knee osteoarthritis.
What are the risks and side effects of fat-derived stem cell treatment for knee osteoarthritis?
The most common side effects of fat-derived stem cell treatment for knee osteoarthritis are injection site pain and swelling. Overall, fat-derived stem cell treatment for knee osteoarthritis is a promising new therapy that has the potential to improve symptoms and slow the progression of the disease.
Why is performing this treatment in Chennai?
Dr. Venkatacham is a pioneer in regenerative medicine in India and has extensive experience with SVF therapy. His institute in Chennai is one of the leading centers for the treatment
Where can you get this treatment?
Contact the doctor by filling a form or call the hospital to fix an appointment.
Suffering from knee arthritis in Chennai? Try PRS treatment
Are you suffering from knee arthritis in Chennai? Try PRS treatment. Watch this video to see how PRS can help you get rid of knee pain and improve your quality of life. PRS treatment is becoming an alternative to total knee replacement among many due to its non-invasiveness, quick results, cost, and durable results. You can see the pre-operative state and post-operative recovery. PRS is a minimally invasive procedure that uses the patient’s stem cells and growth factors to regenerate damaged cartilage and reduce inflammation. The patient was able to walk within a few hours after the treatment with minimal assistance and no pain.
You can see testimonials of more patients here
If you are interested in PRS treatment for knee arthritis, please contact Dr. A.K. Venkatachalam at Madras Joint Replacement Centre. He is one of the leading experts in regenerative medicine and joint replacement surgery in India. Visit his website to learn more about his services and testimonials from his patients.
Evidence for Stem cell treatment knee osteoarthritis Chennai
See the evidence for Stem cell treatment of knee osteoarthritis Chennai discussed in this video. I read from a recently published paper in the Journal of Arthritis Research.
Here’s the video. If interested learn more at www.orthobiologicsurgeryindia.com.
I perform knee replacements, and Orthobiologic procedures.
Stromal vascular fraction (SVF) is a concentrated cell-packed portion of adipose tissue that has been used to treat knee osteoarthritis (OA) 1. SVF is known for its anti-inflammatory characteristics and has been shown to decrease pain and improve function in patients with knee OA 1 2.
In a single-center, non-randomized, phase I/II trial, 33 patients with KL (III) knee osteoarthritis were evaluated. The study aimed to evaluate the improvement in knee pain, function, and cartilage restoration. The results showed that joints treated with SVF provided a better quality of life to patients 1.
Other frequently found interventions include cultured adipose-derived stem cells (ADSCs), and the micronized/microfragmented adipose tissue-stromal vascular fraction (MAT-SVF) 1. Clinical data reported that joints treated with MAT-SVF provided a better quality of life to patients 1.The mechanism of action of SVF is also not fully understood. However, the current hypothesis indicates a direct adherence and integration with the degenerative host tissue, and/or trophic effects resulting from the secretome of constituent cells 1.
In conclusion, there is evidence of efficacy in the use of stromal vascular fraction and related therapy for the treatment of osteoarthritis of the knee. However, more research and clinical patient follow-up are needed to determine the proper place of these therapies in the treatment of osteoarthritis of the knee 1.
Source(s)
1. Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative …
2. Cartilage lesion size and number of stromal vascular fraction (SVF …
3. Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF …
Stem cell treatment knee arthritis Chennai
See the impressive result provided by Stem cell treatment knee arthritis Chennai in this man. He is able to walk without pain. He chose Stem cell treatment or PRS treatment instead of knee replacement. The reason was two botched-up knee replacement operations amongst his family members.
Adipose stem cell treatment is a type of regenerative medicine that uses fat tissue as a source of mesenchymal stem cells (MSCs) to treat knee osteoarthritis (OA). MSCs are multipotent cells that can differentiate into various types of cells, such as cartilage, bone, and muscle. They also have anti-inflammatory and immunomodulatory properties that can promote healing and reduce pain. Adipose stem cell treatment involves harvesting fat tissue from the patient’s own body, usually from the abdomen or thigh, and processing it to isolate the MSCs. The MSCs are then injected into the affected knee joint, where they can potentially regenerate the damaged cartilage and improve joint function.
There are several clinical trials and studies that have evaluated the safety and efficacy of adipose stem cell treatment for knee OA. Some of the results are summarized below:
- A phase I/II, randomized, active-control, single-blind, multiple-center clinical trial compared the intra-articular injection of allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE® with hyaluronic acid (HA) in 57 patients with knee OA1. The results showed that ELIXCYTE® was safe and well-tolerated, and had significant effects on reducing pain and improving function compared to HA. The ELIXCYTE® groups also showed earlier onset and longer duration of effectiveness than the HA group.
- A prospective, randomized, controlled study compared the intra-articular injection of autologous adipose tissue with platelet-rich plasma (PRP) in 60 patients with knee OA2. The study protocol included five assessments before and after the treatment, using patient-reported outcome measures, functional tests, and maximal isometric voluntary contraction.
- A case series reported the outcomes of 10 patients with knee OA who received autologous adipose-derived biocellular stem cell-rich prolotherapy from Hoffa’s fat pad3. The results showed that the treatment improved pain and function scores at 6- and 12-month follow-up, and was associated with increased cartilage thickness and decreased joint effusion on ultrasound imaging.
- A video presentation described a clinical trial to evaluate the safety and efficacy of adipose-derived mesenchymal stromal cell injections as a treatment for patients with knee OA4. The trial involved 25 patients who received two injections of either adipose-derived MSCs or saline placebo at 6-week intervals. The primary outcome was the change in pain score at 6 months. The secondary outcomes included changes in function, quality of life, cartilage volume, and synovial fluid biomarkers. The trial is completed and the results are pending publication.
- A prospective study reported the clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cell therapy in 18 elderly patients with knee OA5. The results showed that the treatment improved pain and function scores at 6- and 12-month follow-up, and was associated with cartilage regeneration and reduced synovitis on arthroscopy.
These studies suggest that adipose stem cell treatment is a promising option for knee OA treatment, especially for elderly patients who have limited options for surgery or pharmacotherapy.
Now watch his performance 5 days after the procedure. He is able to walk comfortably on a slope.
If you want to see more testimonials visit my website
If you are interested in this procedure, fill up the contact form on my website
Platelet rich stroma treatment knee arthritis India
A 75 year old lady with symptoms of knee locking obtained relief after Platelet rich stroma treatment in Chennai. Listen to her testimonial in this video. Dr.A.K.Venkatachalam provides this treatment in Chennai. Although this is a short term honest statement of pain relief by this patient, this study describes the mid term result of SVF treatment at five years. The conclusion in this paper is that 60 percent of patients have acceptable pain relief at five years. This might seem to be sufficient justification for undergoing this procedure which might seem expensive initially.
What is Platelet rich stroma?
Platelet-rich stroma (PRS) is a type of orthobiologic treatment that combines two different types of biological materials: platelet-rich plasma (PRP) and stromal vascular fraction (SVF).
What is PRP?
PRP is a concentrated solution of platelets and growth factors that are derived from a patient’s own blood. It is often used in regenerative medicine to promote tissue healing and reduce inflammation. A concentration of 4 x baseline value of platelets is desirable. PRP provides the growth factors which enable SVF cells to adhere.
What is SVF?
SVF is a mixture of stem cells, immune cells, and other regenerative cells that are derived from adipose tissue (fat). SVF is also known to have regenerative properties. Cells in SVF possess signalling effects. That is they stimulate resident cells within the joint to multiply and produce cartilage matrix. This property of SVF is known as “Paracrine effect” ( See point 4 below)
Stromal vascular fraction (SVF) has been suggested as a potential treatment for knee osteoarthritis due to its ability to combat the inflammatory causes of the condition. SVF contains a mixture of various cells, including mesenchymal stem cells (MSCs), immune cells, and other regenerative cells, which work together to address inflammation and promote tissue healing.
- Anti-inflammatory properties: MSCs within SVF have been found to possess anti-inflammatory properties. They can modulate the immune response and reduce the production of pro-inflammatory molecules, such as cytokines and chemokines. By suppressing inflammation, SVF can help alleviate pain and reduce the progression of knee osteoarthritis.
- Immune modulation: SVF contains immune cells, including regulatory T cells (Tregs), which play a role in immune regulation. Tregs can suppress the activity of other immune cells that contribute to inflammation. This immune modulation by SVF can help control the inflammatory response in the knee joint affected by osteoarthritis.
- Growth factor secretion: SVF cells, including MSCs, have the ability to secrete various growth factors, which can aid in tissue repair and regeneration. These growth factors promote the proliferation and differentiation of cells involved in cartilage and tissue repair, contributing to the healing process in the knee joint affected by osteoarthritis.
- Paracrine effects: SVF cells secrete factors that exert paracrine effects, meaning they influence nearby cells. These paracrine factors can have anti-inflammatory effects and promote tissue regeneration, helping to combat the inflammatory causes of knee osteoarthritis. The resident cartilage forming cells produce cartilage matrix. Cartilage is the weight bearing cushioning material at the ends of bones. Regeneration of cartilage has been observed in this paper.
In PRS treatment, a small amount of adipose tissue is harvested from the patient and processed to extract SVF. The PRP is then combined with the SVF to create the PRS solution. This PRS solution is then injected into the area of injury or degeneration to promote tissue regeneration and repair.
If you wish to get this treatment for yourself, get in touch by filling the contact form in the home page.
Platelet-rich stroma (PRS) treatment knee osteoarthritis India
Platelet-rich stroma treatment for knee osteoarthritis provided amazing pain relief to this lady. Her gait was restored to normal. Listen to her testimonial in this video. To know more about Platelet-rich stroma treatment for knee arthritis, see this post. If you have other orthopaedic problems, see what I can offer here.
What is Platelet-rich stroma?
Platelet-rich stroma treatment is a biologic combination therapy that combines the regenerative properties of both Platelet-rich plasma (PRP) and stromal vascular fraction (SVF) to treat knee osteoarthritis. PRP is a concentrated source of platelets obtained from the patient’s own blood. Platelets contain growth factors and cytokines that promote tissue healing and regeneration. SVF is a mixture of cells that are extracted from adipose tissue. These cells have the ability to differentiate into various cell types and can help repair damaged tissues1.
How is it done?
Platelet-rich stroma treatment is a minimally invasive procedure that involves the injection of PRP and SVF directly into the affected knee joint. The procedure is safe and well-tolerated, with few side effects reported1. It has been found to relieve the pain of osteoarthritis immediately and its effect can last for a few years. Over a period of time, limited cartilage repair is seen2.
If you want this procedure for yourself, seek an appointment with the doctor at the hospital by filling out the contact form in the home page.
Stem cell treatment knee arthritis Chennai
Stem cell treatment knee arthritis Chennai
To know what is stem cell treatment for knee arthritis in Chennai, see this video presentation that was delivered at a medical college in Chennai, India three years ago.
What are stem cells?
Cells that are capable of regenerating and replicating and repairing tissues are known as stem cells. They are present in every organ and tissue in the human body like skin, fat, bone marrow, muscle, and heart, everywhere, but they are dormant and can be kicked into action by external methods either by the response to a trauma or by seeding the damaged area with stem cells by injection or open procedure.
This is the classification of stem cells. At the top, you have the totipotent embryonic stem cell which is formed by the fusion of the sperm to the ova. This results in a zygote and the formation of a blastocyst which further differentiates into two cells four-cell then the embryo and the fetus and so on. The totipotent embryonic stem cell gives rise to pluripotent embryonic stem cells which form various tissues. These pluripotent stem cells then give rise to multipotent stem cells which are present in every tissue like the lung, pancreas, heart muscle, red blood cells skin muscle bone marrow, and every other tissue. These are not confined to the mesenchymal space.
How do we isolate stem cells?
We aspirate them from fat by liposuction. Then we manipulate them by centrifuging. Then they are ready for injection.
Stem cell treatment for knee arthritis in India by Dr.A.K.Venkatachalam is done as an outpatient procedure. The patient can return home within a few hours. If spinal anesthesia is given, then discharge takes longer.
The cells can also be isolated like before and sent off to a tissue bank where they are cultured and stored. By this, their number is expanded to several million and they can be kept in cold storage for longer periods. Certain tissues have got a half-life but some tissues can be stored for a long time. Their potency decreases after one year. So, when these cells are expanded, they can be returned to the doctor to be re-injected into the patient.
How do I apply or treat damaged areas of cartilage and bone?
See this procedure here
One can apply it to the cartilage lesion by arthroscopic or open surgery. Here the joint is inspected through an arthroscope, and the area of damage is prepared by shaving and microfracture. Then the cells are made into a paste with fibrin glue and applied to the cartilage lesion. It is shaped with a spatula. Then the joint is put through a range of movements for the glue to set in five minutes. Then the patient is returned to the ward for observation. He/She will remain non-weight bearing and can resume activities full weight-bearing activities after six weeks. This procedure is usually done for single or one or two cartridge lesions. It does not apply to osteoarthritis wherein I use fluoroscopy or ultrasound guidance for injections.
This is a picture of a slide with seeded chondrocytes
What is the mechanism of action for stem cell treatment of knee arthritis in Chennai?
They have a trophic effect which means they stimulate growth via the secretion of cytokines and growth factors that is when the cells are injected into a joint these growth factors are released and they have the potency or capability of stimulating adjacent cells in the joint to differentiate and form cartilage. These differentiating cells, when stimulated by growth factors, will go ahead and repair areas of damaged cartilage, and limited cartilage repair are possible; not a complete repair in the case of bone on bone.
The cells possess an immune modulatory effect even when injected even from an allergenic source. They erect a barrier between themselves and the native person’s immune system and perform their function without any interference from the destructive and deleterious effects of the immune system like T cells. They have an anti-inflammatory effect. When injected into swollen inflamed joints, they put a brake on inflammation.
After that, there will be continuous improvement.
Antibiotic effect – There is no need for a person to worry when stem cells are injected. They are not at risk of developing a joint infection like septic arthritis of the knee. This is because of the antibiotic effect present in the stem cells themselves.
Self-replication effect- they can replicate as themselves or replication differentiate into further cell types.
They have an anti-aging effect.
What is the role of Stem cells in orthopedic surgery?
The commonest indication is nonunion. In small non-unions stem cells can be injected which can promote union.
Articular cartilage damage in the knee, shoulder, hip, and ankle joints can be treated with stem cells. When stem cells are injected into areas of cartilage damage, they can repair cartilage. They can also repair osteochondral defects when inserted in the form of a bone plug.
Osteoarthritis -When there is widespread cartilage of ICRS grade 3 grade or 2, stem cells can help to halt the ongoing osteoarthritis process and lead to limited repair. Patients can get sustained pain relief for a few years.
Avascular necrosis is commonly seen in the hip joint, and it is bilateral. It can result from steroid intake, alcohol, Gaucher’s disease, and deep-sea diving. Blood disorders like sickle cell anemia can result in avascular necrosis. Avascular necrosis in the early stages can be treated with stem cells.
Stem cells can also promote wound dealing like in diabetic ulcers or chronic ulcers
Advantage of fat over bone marrow.
I injected Stromal vascular fraction (SVF) derived from fat. Earlier I used bone marrow. Fat has several advantages over bone marrow enumerated here.
Bone marrow has fewer stem cells than fat, Fat contains 500 to 2000 times more MSCs than the same volume of bone marrow. Fat cells have the highest proliferation potential, and the cells are younger than bone marrow. in old older people, it may be difficult to obtain cells from the bone marrow because there is osteoporosis. In addition, fat also contains numerous other regenerative cells that are important to the healing process.
A further advantage of fat is that it is less painful. I can aspirate it from the thigh and the patient can go home within a few hours,
Anticoagulants are not required. If you take bone marrow, then you have to treat it immediately with heparin and inject heparin into the bone to prevent it from clotting while being aspirated. This can result in an overdose or leakage of the anticoagulant solution into the adjacent tissue. Bone marrow aspiration from the posterior part of the iliac crest can result in penetration and spread of the heparin in retroperitoneal space, leading to retroperitoneal hematoma.
Cells derived from fat are a better source for articular cartilage repair.
What is the benefit of stem cell treatment for knee arthritis in Chennai?
Some patients have been able to get prolonged pain relief and have postponed knee replacement. The longest follow-up stem cell treatment for the knee is seven years.
See a patient’s testimonial here-
In the short term, they can avoid taking NSAIDs, painkillers, and opioids. They will lead a better quality of life.
So, if you want Stem Cell Treatment for Knee arthritis in Chennai India Dr.A.K.Venkatachalam, click the form, fill it out, and post. You can locate my practice by clicking on this link
Call – 7824003400 or the hospital – 044 42938938
Email -drvenkat@kneeindia.com
SVF treatment knee arthritis Chennai India
Are you suffering from Knee osteoarthritis in Chennai India? If so, you may be wondering if there is an available alternative treatment to knee replacement that can help you. In this video, we will hear from this patient about the reason why she chose SVF treatment. She had seen the failure of knee replacements done elsewhere in other patients This treatment is available in Chennai India and can help you become pain-free!
What is SVF treatment?
Stromal vascular fraction treatment or SVF treatment knee arthritis Chennai India is a new treatment for knee arthritis. It avoids the risks associated with a knee replacement. It is done as a daycare procedure.
In this procedure, the surgeon removes fat from your body by liposuction and processes it in a centrifuge in the operating room. The processed fat contains a mixture of cells, vascular stroma, growth factors, and others. It is then mixed with PRP and then injected into the knee. The procedure takes about an hour for one knee. Patients are able to return home within a few hours. They may feel some discomfort on the first day but the pain will improve.
How is it better than bone marrow treatment?
SVF is derived from fat. It is superior to bone marrow. See this post to know more about the advantages of fat over bone marrow.
Is it better than knee replacement?
According to this lady, she had seen many failures of knee replacement done elsewhere. Other patients have also stated that a knee replacement procedure with its necessary physiotherapy is an ordeal.
What is the evidence for SVF treatment?
SVF treatment is a safe procedure with proven results. A double-blind study has confirmed the effectiveness of SVF therapy. There are other studies that vouch for fat stem cell treatment in knee osteoarthritis. My longest follow-up for stem cell treatment for knee arthritis is seven years. See this video
In this video, this lady states that she had seen many successes of SVF treatment in India by Dr.A.K.Venkatachalam