Platelet-rich stroma (PRS) treatment knee osteoarthritis India

Platelet-rich stroma (PRS) treatment knee osteoarthritis India

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Platelet-rich stroma treatment for knee osteoarthritis provided amazing pain relief to this lady. Her gait was restored to normal. Listen to her testimonial in this video. To know more about Platelet-rich stroma treatment for knee arthritis, see this post. If you have other orthopaedic problems, see what I can offer here. 

What is Platelet-rich stroma?

Platelet-rich stroma treatment is a biologic combination therapy that combines the regenerative properties of both Platelet-rich plasma (PRP) and stromal vascular fraction (SVF) to treat knee osteoarthritis. PRP is a concentrated source of platelets obtained from the patient’s own blood. Platelets contain growth factors and cytokines that promote tissue healing and regeneration. SVF is a mixture of cells that are extracted from adipose tissue. These cells have the ability to differentiate into various cell types and can help repair damaged tissues1.

How is it done?

Platelet-rich stroma treatment is a minimally invasive procedure that involves the injection of PRP and SVF directly into the affected knee joint. The procedure is safe and well-tolerated, with few side effects reported1. It has been found to relieve the pain of osteoarthritis immediately and its effect can last for a few years. Over a period of time, limited cartilage repair is seen2.

If you want this procedure for yourself, seek an appointment with the doctor at the hospital by filling out the contact form in the home page.

 

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Platelet-rich stroma procedure explained

Platelet-rich stroma procedure explained – treatment for knee OA

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Watch a Platelet-rich stroma procedure performed for a case of knee osteoarthritis. The patient has advanced OA changes as seen on 3T MRI and cartigram.

What is Platelet-rich stroma?


Platelet-rich stroma (PRS) is a combination of platelet-rich plasma (PRP) and stromal vascular fraction (SVF). PRS includes stromal cells in their matrix with stimulating factors and plays an important role in reducing articular inflammation and signalling cartilage repair in osteoarthritis. It contains SVF obtained from fat. Fat is a better source of multipotential signaling cells than bone marrow. Tissue SVF is combined with Platele-rich plasma (PRP) before intra-articular injection. Fat is harvested by mini liposuction from the thigh, buttocks, or abdominal fat through tiny incisions. The incisions heal naturally without sutures.

PRP is prepared from venous blood. It concentrates platelets several fold times. Platelets contain growth factors which assist in tissue repair.

It is injected into the knee under ultrasound guidance. Ultrasound-guided knee injections are more accurate than blind injections. Keyhole surgery (arthroscopy) or spinal anesthesia is not involved in my procedure. Platelet-rich stroma is a revolutionary procedure to treat osteoarthritis of the knee. Platelet-rich stroma relieves the pain of osteoarthritis immediately and its effect can last for a few years. Over a period of time limited cartilage repair is seen. See the technique of ultrasound-guided PRS injection here.  Platelet-rich stroma is preferred by many patients nowadays as an alternative to knee replacement 

How is it done?

The procedure is performed under local anaaesthesia. It is injected under ultrasound guidance. Ultrasound-guided knee injections are more accurate than blind injections. Keyhole surgery (arthroscopy) or spinal anesthesia is not involved in my procedure.

No spinal anesthesia is required. Keyhole surgery is not used. Both knees can be done in one sitting.  The patient walks into the OR and walks out after the procedure. They experience immediate pain relief. PRS, SVFhttps://www.orthobiologicsurgeryindia.com and PRP are commonly performed biologic injections in my practice. I also perform knee replacements for advanced cases of knee arthritis. ACL reconstruction, and meniscal repair, are the common arthroscopic procedures.

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Platelet rich stroma treatment knee arthritis Chennai

Platelet rich stroma treatment knee arthritis Chennai

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Listen to a patient’s testimonial for platelet rich stroma (PRS)  treatment knee arthritis Chennai. This lady was able to walk within a few hours of the treatment.

Platelet-rich stroma (PRS) treatment for knee osteoarthritis (OA) is a promising therapeutic option that has shown significant potential recently. This approach involves the use of the patient’s own blood and tissue which is processed to extract concentrated Platelet rich stroma. This PRS is then injected directly into the knee joint without any key hole surgery under local anaesthesia.  Inside the joint PRS can stimulate the body’s natural healing response and help repair damaged tissues.

The effectiveness of PRS and SVF treatment for knee OA has been extensively studied in the literature, with a growing body of evidence suggesting that it can provide significant pain relief and improve function in patients with this condition

The positive result in this patient and others suggest that PRS treatment has significant potential as a non-invasive, low-risk therapeutic option for patients with knee OA. However, it is important to note that more research is needed to fully understand the mechanisms by which PRS treatment works and to optimize treatment protocols for different patient populations.

In conclusion, PRS treatment for knee OA is an exciting new option that holds significant promise for patients seeking relief from this debilitating condition. With further research and refinement, it is likely that PRS treatment will become an increasingly important part of the toolkit of healthcare providers seeking to improve outcomes for patients with knee OA

Listen to a patient’s testimonial here

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PRS treatment knee arthritis India

PRS treatment knee Osteoarthritis India

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Are you sick of seeing knee replacements fail among relatives and friends? So did this gentleman from Kolkata who was disillusioned with the hardships that his close relatives faced after a knee replacement. He decided to get a platelet-rich stroma ( PRS) treatment for his knee arthritis. Listen to his testimonial here. Many patients have benefited from PRS or SVF treatment in Chennai

What is PRS treatment?

Platelet-rich stroma (PRS) treatment in Chennai, India is a cutting-edge therapy for knee osteoarthritis (OA) that utilizes the patient’s own adipose (fat) tissue and PRP to promote healing and reduce pain. The treatment begins with a liposuction procedure to harvest adipose tissue from the patient’s thigh. The tissue is then processed to isolate stromal vascular fraction (SVF), which is a rich mixture of cells that include adipose-derived stem cells, endothelial cells, and other stromal cells. Once the SVF is prepared, it is mixed with platelet-rich plasma (PRP) to yield PRS, which is injected directly into the knee joint, where it can promote healing and repair of the damaged cartilage. The stem cells in the SVF can differentiate into various types of cells, including chondrocytes (cartilage cells), which can help to rebuild the damaged cartilage in the knee joint. Additionally, the SVF can stimulate the production of growth factors and other molecules that promote healing and reduce inflammation. PRP provides growth factors.

What is the result of PRS treatment

PRS treatment is a minimally invasive procedure that is performed on an outpatient basis. Patients typically experience minimal pain and discomfort during the procedure and can return to normal activities within a few days. The effects of the treatment can be seen within a few weeks and may continue to improve over time. Overall, PRS treatment for knee OA is a promising new therapy that utilizes the patient’s own cells to promote healing and reduce pain. It is a safe and effective option for patients who are seeking an alternative to traditional treatments such as surgery or medication. Platelet-rich stroma was injected into both knees of this gentleman for knee osteoarthritis, following which he has made a quick recovery.

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Stem cell treatment knee arthritis Chennai

Stem cell treatment knee arthritis Chennai

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Stem cell treatment knee arthritis Chennai
To know what is stem cell treatment for knee arthritis in Chennai, see this video presentation that was delivered at a medical college in Chennai, India three years ago.

What are stem cells?

Cells that are capable of regenerating and replicating and repairing tissues are known as stem cells. They are present in every organ and tissue in the human body like skin, fat, bone marrow, muscle, and heart, everywhere, but they are dormant and can be kicked into action by external methods either by the response to a trauma or by seeding the damaged area with stem cells by injection or open procedure.

This is the classification of stem cells. At the top, you have the totipotent embryonic stem cell which is formed by the fusion of the sperm to the ova. This results in a zygote and the formation of a blastocyst which further differentiates into two cells four-cell then the embryo and the fetus and so on. The totipotent embryonic stem cell gives rise to pluripotent embryonic stem cells which form various tissues. These pluripotent stem cells then give rise to multipotent stem cells which are present in every tissue like the lung, pancreas, heart muscle, red blood cells skin muscle bone marrow, and every other tissue. These are not confined to the mesenchymal space.

How do we isolate stem cells?

We aspirate them from fat by liposuction. Then we manipulate them by centrifuging. Then they are ready for injection.

Stem cell treatment for knee arthritis in India by Dr.A.K.Venkatachalam is done as an outpatient procedure. The patient can return home within a few hours. If spinal anesthesia is given, then discharge takes longer.

The cells can also be isolated like before and sent off to a tissue bank where they are cultured and stored.  By this, their number is expanded to several million and they can be kept in cold storage for longer periods. Certain tissues have got a half-life but some tissues can be stored for a long time.  Their potency decreases after one year. So, when these cells are expanded, they can be returned to the doctor to be re-injected into the patient.

How do I apply or treat damaged areas of cartilage and bone?

See this procedure here 

One can apply it to the cartilage lesion by arthroscopic or open surgery. Here the joint is inspected through an arthroscope, and the area of damage is prepared by shaving and microfracture. Then the cells are made into a paste with fibrin glue and applied to the cartilage lesion. It is shaped with a spatula. Then the joint is put through a range of movements for the glue to set in five minutes. Then the patient is returned to the ward for observation. He/She will remain non-weight bearing and can resume activities full weight-bearing activities after six weeks. This procedure is usually done for single or one or two cartridge lesions.  It does not apply to osteoarthritis wherein I use fluoroscopy or ultrasound guidance for injections.

This is a picture of a slide with seeded chondrocytes

What is the mechanism of action for stem cell treatment of knee arthritis in Chennai?

They have a trophic effect which means they stimulate growth via the secretion of cytokines and growth factors that is when the cells are injected into a joint these growth factors are released and they have the potency or capability of stimulating adjacent cells in the joint to differentiate and form cartilage. These differentiating cells, when stimulated by growth factors, will go ahead and repair areas of damaged cartilage, and limited cartilage repair are possible; not a complete repair in the case of bone on bone.

The cells possess an immune modulatory effect even when injected even from an allergenic source. They erect a barrier between themselves and the native person’s immune system and perform their function without any interference from the destructive and deleterious effects of the immune system like T cells. They have an anti-inflammatory effect. When injected into swollen inflamed joints, they put a brake on inflammation.

After that, there will be continuous improvement.

Antibiotic effect – There is no need for a person to worry when stem cells are injected. They are not at risk of developing a joint infection like septic arthritis of the knee. This is because of the antibiotic effect present in the stem cells themselves.

Self-replication effect- they can replicate as themselves or replication differentiate into further cell types.

They have an anti-aging effect.

What is the role of Stem cells in orthopedic surgery?

The commonest indication is nonunion.  In small non-unions stem cells can be injected which can promote union.

Articular cartilage damage in the knee, shoulder, hip, and ankle joints can be treated with stem cells.  When stem cells are injected into areas of cartilage damage, they can repair cartilage. They can also repair osteochondral defects when inserted in the form of a bone plug.

Osteoarthritis -When there is widespread cartilage of ICRS grade 3 grade or 2, stem cells can help to halt the ongoing osteoarthritis process and lead to limited repair. Patients can get sustained pain relief for a few years.

Avascular necrosis is commonly seen in the hip joint, and it is bilateral. It can result from steroid intake, alcohol, Gaucher’s disease, and deep-sea diving. Blood disorders like sickle cell anemia can result in avascular necrosis. Avascular necrosis in the early stages can be treated with stem cells.

Stem cells can also promote wound dealing like in diabetic ulcers or chronic ulcers

Advantage of fat over bone marrow.

I injected Stromal vascular fraction (SVF) derived from fat.  Earlier I used bone marrow. Fat has several advantages over bone marrow enumerated here.

Bone marrow has fewer stem cells than fat, Fat contains 500 to 2000 times more MSCs than the same volume of bone marrow. Fat cells have the highest proliferation potential, and the cells are younger than bone marrow. in old older people, it may be difficult to obtain cells from the bone marrow because there is osteoporosis. In addition, fat also contains numerous other regenerative cells that are important to the healing process.

A further advantage of fat is that it is less painful. I can aspirate it from the thigh and the patient can go home within a few hours,

Anticoagulants are not required. If you take bone marrow, then you have to treat it immediately with heparin and inject heparin into the bone to prevent it from clotting while being aspirated. This can result in an overdose or leakage of the anticoagulant solution into the adjacent tissue. Bone marrow aspiration from the posterior part of the iliac crest can result in penetration and spread of the heparin in retroperitoneal space, leading to retroperitoneal hematoma.

Cells derived from fat are a better source for articular cartilage repair.

What is the benefit of stem cell treatment for knee arthritis in Chennai?

Some patients have been able to get prolonged pain relief and have postponed knee replacement. The longest follow-up stem cell treatment for the knee is seven years.

See a patient’s testimonial here-

In the short term, they can avoid taking NSAIDs, painkillers, and opioids. They will lead a better quality of life.

So, if you want Stem Cell Treatment for Knee arthritis in Chennai India Dr.A.K.Venkatachalam, click the form, fill it out, and post. You can locate my practice by clicking on this link

Call – 7824003400 or the hospital – 044 42938938

Email -drvenkat@kneeindia.com

 

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SVF treatment knee arthritis Chennai India

SVF treatment knee arthritis Chennai India

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Are you suffering from Knee osteoarthritis in Chennai India? If so, you may be wondering if there is an available alternative treatment to knee replacement that can help you. In this video, we will hear from this patient about the reason why she chose SVF treatment. She had seen the failure of knee replacements done elsewhere in other patients This treatment is available in Chennai India and can help you become pain-free!

What is SVF treatment?

Stromal vascular fraction treatment or SVF treatment knee arthritis Chennai India is a new treatment for knee arthritis. It avoids the risks associated with a knee replacement. It is done as a daycare procedure.

In this procedure, the surgeon removes fat from your body by liposuction and processes it in a centrifuge in the operating room. The processed fat contains a mixture of cells, vascular stroma, growth factors, and others. It is then mixed with PRP and then injected into the knee. The procedure takes about an hour for one knee. Patients are able to return home within a few hours. They may feel some discomfort on the first day but the pain will improve.

How is it better than bone marrow treatment?

SVF is derived from fat. It is superior to bone marrow. See this post to know more about the advantages of fat over bone marrow.

Is it better than knee replacement?

According to this lady, she had seen many failures of knee replacement done elsewhere. Other patients have also stated that a knee replacement procedure with its necessary physiotherapy is an ordeal.

What is the evidence for SVF treatment?

SVF treatment is a safe procedure with proven results. A double-blind study has confirmed the effectiveness of SVF therapy. There are other studies that vouch for fat stem cell treatment in knee osteoarthritis. My longest follow-up for stem cell treatment for knee arthritis is seven years. See this video 

In this video, this lady states that she had seen many successes of SVF treatment in India by Dr.A.K.Venkatachalam

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Stem cell treatment knee arthritis Chennai

Stem cell treatment Knee osteoarthritis Chennai

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Stem cell treatment Knee osteoarthritis Chennai

Learn about Stem cell treatment Knee osteoarthritis Chenna

What stem cells do I use?

I use fat for stem cell treatment of knee osteoarthritis in Chennai, India.

Cellular therapy with stem cells acts by stopping the relentless progress of knee osteoarthritis. It can regenerate and repair cartilage in the early stages of osteoarthritis. Thus, it can postpone the requirement for a knee replacement by several years. I use cells derived from adipose tissue or fat. I harvest fat from your body and prepare it in the operating theatre. Stromal vascular fraction is derived from this which is injected into the knee joint with ultrasound guidance. Pain relief lasts for one to three years and this can be repeated if any. Alternatively, one can culture these cells in a tissue bank and reuse them later. This will avoid further surgery. One can postpone a knee replacement by several years with this treatment. I use fat for my treatments as it is much superior to bone marrow. When both knees are involved, I operate on both knees in the same session. No anesthesia is required. The patient can go home the same day after the treatment. Pain relief starts immediately and can last for a few years. Many patients are scared of getting a knee replacement and prefer a cellular therapy procedure after full information has been conveyed to them. If you want an appointment, fill out the contact form at   https://orthobiologicsurgeryindia.com/contact-us/

 

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PRP therapy knee arthritis Chennai

Platelet-rich plasma (PRP) treatment Chennai.

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Platelet-rich plasma (PRP) treatment Chennai.

What are platelets?

Platelets are a type of cell in the blood primarily responsible for clotting. In addition to their paramount clotting function, they can also perform tissue repair as they also contain chemicals known as growth factors inside one of the three types of granules inside them which support healing and recovery processes. Platelets have three types of granules inside them known as α–granules, dense granules, and lysosomes. These granules are released when platelets encounter external tissues. Platelets swell and burst and release their granules.

What is Platelet-rich plasma?

Platelet-rich Plasma (PRP) is a filtrate of plasma rich in platelets. It contains plasma which is the liquid portion of blood and one of the three types of blood cells called platelets. In PRP, plasma contains significantly more platelets than their baseline value in blood, so the concentration of growth factors can be five to 10 times higher.

How is Platelet-rich plasma prepared for injection?

To create platelet-rich plasma, doctors take a blood sample from the patient and place it into a device called a centrifuge that rapidly spins the sample, separating out the other components of the blood from the platelets and concentrating them within the plasma. See how PRP is prepared in this video.

What is the basis for the actions of platelets?

Platelets are known to provide a diverse array of growth factors that can work independently or with other proteins and cells to improve the healing process. Although the use of PRP in the dermatology and maxillofacial fields dates to more than 50 years, the study and application of this treatment in joint conditions is recent and growing. As mentioned before, the biological rationale for the clinical use of PRP includes the local action of growth factors, the modification of the inflammatory response, and the effects on cell proliferation and differentiation.

Which are the principal areas of the musculoskeletal tissue in which PRP is being used?

Intraarticular platelet-rich plasma (PRP) injection has emerged as a promising treatment for knee osteoarthritis. Studies to date, including multiple randomized controlled trials, have shown that PRP is a safe and effective treatment option for knee osteoarthritis. Intra-articular PRP is similar in efficacy to hyaluronic acid and seems to be more effective than hyaluronic acid in younger, active patients with low-grade osteoarthritis. Treatment benefits wane after 6-9 months Intraarticular platelet-rich plasma injection in the treatment of knee osteoarthritis: review and recommendations – PubMed (nih.gov)

In addition, they are used to heal tendon, fascia, and ligament degenerative conditions and tears. They are also used to initiate the repair of peripheral nerves like the ulnar and median nerves when these are enlarged and compressed in the elbow and palm as in cubital tunnel and carpal tunnel syndromes.

PRP is also used to accelerate ACL repairs and meniscal repairs in the knee. PRP can be combined with the Stromal vascular fraction to yield platelet-rich stroma (PRS). This is used to treat knee Osteoarthritis, avascular necrosis, and cartilage lesions.

See how PRP injection alleviated this gentleman’s knee pain-

Platelet-rich plasma (PRP) treatment for knee cartilage lesions and osteoarthritis Chennai.

Listen to how a young man benefited from a PRP injection to his shoulder in this video

See how effective PRP was for treating heel pain in this video

If you wish to make an appointment e mail me at drvenkat@kneeindia.com or call the hospital number at +91 44 42938938.

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Stem cell treatment knee osteoarthritis India

Stem cell treatment knee osteo-arthritis India

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Stem cell treatment Knee osteoarthritis India. Listen to a West Bengal patient’s experience. Her ten-year-old suffering was relieved after fat stem cell treatment in Chennai. She felt immediate relief. She didn’t want a knee replacement at this stage as she was frightened of the pain during and after the procedure.

She was overjoyed that this procedure was rapidly and painlessly done. She felt pain relief the next day after the procedure. On current follow-up via a telephone conversation, her condition has greatly improved.

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