A-Kavach– The Biological Shield That Protects Your Joints From Arthritis

A-Kavach™ – The Biological  shield That Protects Your Joints From Arthritis

Arthritis is not just “wear and tear.” For decades, patients were told that their cartilage simply eroded because of aging or excessive load. But modern mechano-biologic science reveals a much more complex—and more important—truth:

Your knee is under a chemical attack.

Inside an arthritic joint, destructive enzymes (proteases), inflammatory molecules, and oxidative stress behave like microscopic knives, cutting through cartilage and accelerating degeneration. Even if your X-ray looks “mild,” the chemical destruction can be severe.

A-Kavach™ is designed to stop this destruction before true damage occurs.


Why the Old “Wear and Tear” Theory Is Outdated

For years, osteoarthritis was explained only as a mechanical problem. But today we know that:

  • Cartilage breakdown is driven by biochemical inflammation
  • Specific enzymes—MMPs, ADAMTS, and cytokines—dissolve collagen and proteoglycans
  • These changes start silently, long before severe X-ray findings
  • This is why some patients with “normal” X-rays have severe pain
  • And some people with terrible X-rays have no pain at all

Mechanical load alone does NOT cause arthritis. Chemical assault does.

A-Kavach™ is built specifically to interrupt this chemical cascade.


What Is A-Kavach™?

A-Kavach™ is a biological defence protocol designed at Madras Rejuvenation Centre to protect your cartilage from the destructive forces of osteoarthritis.

It works through a 3-layered mechanism:

1. Shielding the cartilage from destructive enzymes

Biologic agents used in A-Kavach™ neutralize excess proteases and inflammatory molecules. This slows the chemical erosion that silently eats away at cartilage.

2. Improving joint biology and nutrient flow

Healthy cartilage depends on movement, pressure gradients, and cellular health. A-Kavach™ restores the biological environment needed for repair.

3. Reducing pain generators inside the joint

Pain signals come from:

  • Synovial inflammation
  • Bone marrow lesions
  • Nerve sensitization
  • Piezo-mechanoreceptor dysfunction

A-Kavach™ addresses these pain pathways to restore comfort and confidence.


Who Is A-Kavach™ For?

A-Kavach™ is ideal for patients who:

  • Have early to moderate osteoarthritis
  • Experience pain not explained by X-ray severity
  • Want to avoid or delay knee replacement
  • Have active inflammation inside the joint
  • Prefer a PR to joint preservation
  • Want to maintain mobility and function for years to come

Patients with metabolic syndrome, obesity, or chronic inflammation benefit significantly because A-Kavach™ directly targets “chemical arthritis.”


Why Timing Matters: The Earlier, the Better

By the time advanced arthritis appears on X-ray, a lot of cartilage is already lost. But the chemical destruction begins years earlier.

A-Kavach™ is your opportunity to intervene at the right time—not when the joint is already beyond biological rescue.

This is why early diagnosis and early biologic intervention are critical.


A-Kavach™ vs Conventional Arthritis Care

Treatment What It Does Limitations
Painkillers Reduce pain Do not stop damage; may accelerate cartilage loss
Steroid injections Quick relief Short-term, can worsen long-term arthritis
Physiotherapy Improves mechanics Cannot neutralize biochemical attack
Knee replacement Final-stage solution Major surgery, not for early OA
A-Kavach™ Targets chemical destruction + protects cartilage Best in early and moderate OA

The Science Behind the Shield

The A-Kavach™ protocol is rooted in:

  • Mechano-biology
  • Inflammation control
  • Cartilage protection science
  • Modulation of joint biochemical environment
  • Understanding of pain-generation pathways
  • Regenerative orthobiologic principles

This is a future-ready, precision-designed arthritis defence system.


Expected Outcomes With A-Kavach™

Most patients experience:

  • Reduced pain and swelling
  • Improved walking tolerance
  • Better stair-climbing ability
  • Increased knee confidence
  • Reduced night pain
  • Slowing of disease progression
  • Delayed or avoided knee replacement

Because A-Kavach™ addresses root biochemical causes, not just symptoms.


Take the First Step Towards Joint Protection

Arthritis progression is not inevitable. The chemical assault can be slowed—sometimes dramatically—when addressed early and correctly.

A-Kavach™ is your biological shield. Let your knees fight back.

To learn more or book a consultation, visit:
www.orthobiologicsurgeryindia.com
www.drakvenkat.com

The Scientific Evidence Behind Inflammation-First Knee Arthritis Care

  1. Scientific Basis of Inflammation-First Knee Arthritis Care

This page summarises the scientific evidence supporting an inflammation-first approach to knee osteoarthritis, as presented in the Inflammation Pillar Video. Each section corresponds directly to a key statement from the script, supported by peer-reviewed research.

1. Knee Arthritis Is Not Just Wear and Tear

Scientific Proof

Osteoarthritis is now recognised as a whole-joint inflammatory disease involving the synovium, cartilage, subchondral bone, ligaments, and infrapatellar fat pad.

Key References

  • Robinson WH et al., Nature Reviews Rheumatology – Osteoarthritis as an inflammatory disease
  • Berenbaum F, Osteoarthritis and Cartilage – Low-grade chronic inflammation in OA progression

Consensus

Mechanical damage alone does not explain pain severity or disease progression.


2. Inflammation Inside the Joint Drives Pain, Stiffness, and Progression

Scientific Proof

  • Synovitis strongly correlates with pain severity
  • Associated with effusion and stiffness
  • Predicts faster cartilage loss

Key References

  • Hill CL et al., Annals of the Rheumatic Diseases
  • Felson DT et al., Arthritis & Rheumatology

Consensus

Pain tracks inflammatory activity, not X-ray grade.


3. Two Patients With the Same X-Ray Can Have Very Different Pain

Scientific Proof

Radiographic severity correlates poorly with clinical symptoms.

Key References

  • Bedson J, Croft PR, Rheumatology
  • Hannan MT et al., Arthritis & Rheumatism

Consensus

Imaging underestimates biological disease activity.


4. Exercise Improves Support, Not Inflammation

Scientific Proof

  • Improves muscle strength and neuromuscular control
  • Does not suppress synovial cytokines when inflammation is active

Key References

  • Henriksen M et al., Osteoarthritis and Cartilage
  • Baker KR et al., Arthritis Care & Research

Consensus

Exercise is necessary but biologically insufficient when inflammation is uncontrolled.


5. Why Patients Plateau Despite Good Physiotherapy

Scientific Proof

  • Active synovitis predicts poor rehabilitation response
  • Associated with pain flares after loading
  • Reduces tolerance to strengthening

Key References

  • Scanzello CR et al., Clinical Orthopaedics and Related Research
  • Schaible HG, Nature Reviews Rheumatology

Consensus

Plateaus are biological, not motivational failures.


6. Painkillers Suppress Symptoms, Not Disease Biology

Scientific Proof

  • NSAIDs reduce pain temporarily
  • Do not halt cartilage degeneration
  • Do not modify disease progression

Key References

  • Zhang W et al., OARSI Guidelines
  • Hochberg MC et al., Arthritis Care & Research

Consensus

Symptom relief does not equal disease control.


7. Sequence Matters: Calm Inflammation Before Strengthening

Scientific Proof

  • Reducing inflammatory load improves pain thresholds
  • Improves exercise tolerance
  • Enhances functional outcomes

Key References

  • Atukorala I et al., Arthritis Research & Therapy
  • Bennell KL et al., British Journal of Sports Medicine

Consensus

Biological readiness determines rehabilitation success.


8. Joint Preservation Focuses on Biology, Not Just Mechanics

Scientific Proof

Modern OA management emphasises early biological modulation, load management, and individualised treatment sequencing.

Key References

  • Loeser RF et al., Osteoarthritis and Cartilage
  • Hunter DJ, The Lancet

Consensus

Joint preservation is proactive, not passive.


9. Inflammation Is Treatable

Scientific Proof

  • Inflammation in OA is measurable
  • Inflammation is modifiable
  • Inflammation is clinically meaningful

Key References

  • Mathiessen A, Conaghan PG, Arthritis Research & Therapy
  • Scanzello CR, Goldring SR, Arthritis & Rheumatology

Consensus

Osteoarthritis inflammation is manageable, not inevitable.

See the video here -https://youtu.be/IJFPdKUwpc0?si=5lN4781-zEmo3Xk0

FAQ’s

Q: Is knee osteoarthritis only caused by wear and tear?

A: No. Current research shows osteoarthritis is a whole-joint inflammatory disease. Mechanical wear alone does not explain pain severity or progression.

Q: Why does knee pain not match X-ray findings?

A: Pain correlates more strongly with synovial inflammation than with radiographic cartilage loss. X-rays underestimate biological disease activity.

Q: Does exercise reduce inflammation in knee arthritis?

A: Exercise improves strength and support but does not reliably suppress active synovial inflammation when it is present.

Q: Why do some patients plateau despite physiotherapy?

A: Active inflammation sensitises pain pathways and limits tolerance to loading, leading to biological—not motivational—plateaus.

Q: Are painkillers disease-modifying in knee arthritis?

A: No. NSAIDs reduce symptoms temporarily but do not alter the underlying disease process or progression.

Five year success of PRP injection to left knee & TKR to right knee Dr.A.K.Venkatachalam

PRP treatment knee arthritis 5 year success story

PRP treatment knee arthritis success story

Long-Term Pain Relief and Functional Improvement:

  • 70-year-old  Mrs.Swarnalatha  underwent PRP injections five years ago for moderate knee osteoarthritis. She reports sustained pain relief and increased joint function, allowing her to participate in activities he previously avoided due to pain.
  • She had a knee replacement in one knee by Dr.A.K.Venkatachalam
  •  In this video, a seventy-three-year-old lady shares her 5-year success of PRP injection to left knee and Total knee replacement to right knee for OA knee. Her surgery was in early 2019 and the original diagnosis was OA knee. She was treated with a PRP injection in her left knee and a total knee replacement in her right knee. The results are as follows: 1. PRP injection: After injection, she had improved range of motion (ROM), less pain, and improved quality of life. 2. Total knee replacement to right knee: After surgery, she had improved range of motion (ROM), less pain, and improved quality of life. She also regained her walking speed and strength.

Platelet-rich stroma procedure explained

What is Platelet rich stroma (PRS) treatment for knee osteoarthritis?

Platelet-rich stroma treatment for knee osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease that affects millions of people worldwide. It causes pain, stiffness, and reduced mobility in the affected joints. One of the most common sites of OA is the knee, which bears a lot of weight and stress during daily activities.

There is no cure for OA, but there are various treatments that can help manage the symptoms and slow down the progression of the disease. One of these treatments is platelet-rich stroma (PRS), which is a type of regenerative medicine that uses the patient’s own blood cells to stimulate the healing and repair of damaged tissues.

What is Platelet-rich stroma treatment?

PRS is derived from the patient’s blood and adipose tissue which are drawn and processed in a high-end device that separates and concentrates the platelets and SVF. The PRS is then injected into the affected knee joint under ultrasound guidance, where it releases various bioactive molecules that promote inflammation, angiogenesis, and tissue regeneration.

To explain how PRS works, we need to understand how platelets and growth factors function in the body. Platelets are small blood cells that are involved in blood clotting and wound healing. They contain granules that store various growth factors, which are proteins that can signal other cells to grow, divide, or differentiate. Growth factors can also modulate inflammation, which is a natural response to injury or infection.

When PRS is injected into the knee joint, it creates a microenvironment that mimics a wound site. The platelets become activated and release their growth factors, which attract and activate other cells such as stem cells, fibroblasts, and endothelial cells. These cells then start to produce new collagen, blood vessels, and cartilage matrix, which can restore some of the lost tissue function and structure.

PRS has been shown to have beneficial effects on knee OA in several clinical trials. It can reduce pain, improve function, and enhance the quality of life for patients with mild to moderate OA. It can also delay or prevent the need for more invasive procedures such as joint replacement surgery.

PRS is a safe and minimally invasive procedure that can be performed in an outpatient setting. It has few side effects and a low risk of infection or rejection.

If you are suffering from knee OA and are interested in PRS, you should consult Dr. A.K. Venkatachalam and discuss the pros and cons of this treatment option. PRS may not be suitable for everyone as it depends on the severity of OA and individual expectations.

References:

: Venkatachalam A.K. Knee osteoarthritis treatment Platelet-rich stroma India. Ortho Biologic Surgery India Blog 2023; https://orthobiologicsurgeryindia.com/knee-osteoarthritis-treatment-with-platelet-rich-stroma-in-india/

: Venkatachalam A.K. Platelet-rich stroma procedure Knee arthritis Chennai. Ortho Biologic Surgery India Blog 2023; https://orthobiologicsurgeryindia.com/platelet-rich-stroma-procedure-explained-treatment-for-knee-oa/

: Venkatachalam A.K., What is platelet-rich stroma treatment for knee osteoarthritis in Chennai India? Dr.A.K.Venkatachalam’s MJRC Clinic 2023; https://drakvenkat.com/what-is-platelet-rich-stroma-treatment-for-knee-osteoarthritis-in-chennai-india/

Knee joint preservation with PRP injection in Chennai

Knee joint preservation with PRP injection in Chennai

Knee joint preservation with PRP injection in Chennai.

See how a Maldivian patient got relief with PRP injections in Chennai to both knees. He was instantly relieved of his pain and could walk without any pain. He had been suffering from pain for the last 12 years. He didn’t want to undergo a knee replacement as he wanted to kneel and pray five times a day. He was influenced by the recommendation of a former patient who had undergone autologous chondrocyte implantation previously. PRP is a biologic injection that alleviates pain and restores mobility.

PRP therapy knee arthritis Chennai

PRP treatment Knee osteo-arthritis Chennai Dr.A.K.Venkatachalam

This gentleman underwent PRP treatment for knee osteo-arthritis in Chennai by Dr.A.K.Venkatachalam. He had undergone stem cell treatment for both his knees earlier three years ago. Although the pain wasn’t severe, he was developing mild discomfort which he wanted to put an end to. He had noticed a decline in function recently and wanted to improve his walking time.If you need PRP treatment.
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