Evidence for Stem cell treatment knee osteoarthritis India

Evidence for Stem cell treatment knee osteoarthritis Chennai

See the evidence for Stem cell treatment of knee osteoarthritis Chennai discussed in this video. I read from a recently published paper in the Journal of Arthritis Research.

Here’s the video. If interested learn more at www.orthobiologicsurgeryindia.com. 

I perform knee replacements, and Orthobiologic procedures.

Stromal vascular fraction (SVF) is a concentrated cell-packed portion of adipose tissue that has been used to treat knee osteoarthritis (OA) 1. SVF is known for its anti-inflammatory characteristics and has been shown to decrease pain and improve function in patients with knee OA 1 2.

In a single-center, non-randomized, phase I/II trial, 33 patients with KL (III) knee osteoarthritis were evaluated. The study aimed to evaluate the improvement in knee pain, function, and cartilage restoration. The results showed that joints treated with SVF provided a better quality of life to patients 1.

Other frequently found interventions include cultured adipose-derived stem cells (ADSCs), and the micronized/microfragmented adipose tissue-stromal vascular fraction (MAT-SVF) 1. Clinical data reported that joints treated with MAT-SVF provided a better quality of life to patients 1.The mechanism of action of SVF is also not fully understood. However, the current hypothesis indicates a direct adherence and integration with the degenerative host tissue, and/or trophic effects resulting from the secretome of constituent cells 1.

In conclusion, there is evidence of efficacy in the use of stromal vascular fraction and related therapy for the treatment of osteoarthritis of the knee. However, more research and clinical patient follow-up are needed to determine the proper place of these therapies in the treatment of osteoarthritis of the knee 1.

Source(s)

1. Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative …

2. Cartilage lesion size and number of stromal vascular fraction (SVF …

3. Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF …

Platelet rich stroma treatment for knee arthritis India

Platelet rich stroma treatment knee arthritis India

A 75 year old lady with symptoms of knee locking obtained relief after Platelet rich stroma treatment in Chennai. Listen to her testimonial in this video. Dr.A.K.Venkatachalam provides this treatment in Chennai. Although this is a short term honest statement of pain relief by this patient, this study describes the mid term result of SVF treatment at five years. The conclusion in this paper is that 60 percent of patients have acceptable pain relief at five years. This might seem to be sufficient justification for undergoing this procedure which might seem expensive initially.

What is Platelet rich stroma?

Platelet-rich stroma (PRS) is a type of orthobiologic treatment that combines two different types of biological materials: platelet-rich plasma (PRP) and stromal vascular fraction (SVF).

What is PRP?

PRP is a concentrated solution of platelets and growth factors that are derived from a patient’s own blood. It is often used in regenerative medicine to promote tissue healing and reduce inflammation. A concentration of 4 x baseline value of platelets is desirable. PRP provides the growth factors which enable SVF cells to adhere.

What is SVF?

SVF is a mixture of stem cells, immune cells, and other regenerative cells that are derived from adipose tissue (fat). SVF is also known to have regenerative properties. Cells in SVF possess signalling effects. That is they stimulate resident cells within the joint to multiply and produce cartilage matrix. This property of SVF is known as “Paracrine effect” ( See point 4 below)

Stromal vascular fraction (SVF) has been suggested as a potential treatment for knee osteoarthritis due to its ability to combat the inflammatory causes of the condition. SVF contains a mixture of various cells, including mesenchymal stem cells (MSCs), immune cells, and other regenerative cells, which work together to address inflammation and promote tissue healing.

  1. Anti-inflammatory properties: MSCs within SVF have been found to possess anti-inflammatory properties. They can modulate the immune response and reduce the production of pro-inflammatory molecules, such as cytokines and chemokines. By suppressing inflammation, SVF can help alleviate pain and reduce the progression of knee osteoarthritis.
  2. Immune modulation: SVF contains immune cells, including regulatory T cells (Tregs), which play a role in immune regulation. Tregs can suppress the activity of other immune cells that contribute to inflammation. This immune modulation by SVF can help control the inflammatory response in the knee joint affected by osteoarthritis.
  3. Growth factor secretion: SVF cells, including MSCs, have the ability to secrete various growth factors, which can aid in tissue repair and regeneration. These growth factors promote the proliferation and differentiation of cells involved in cartilage and tissue repair, contributing to the healing process in the knee joint affected by osteoarthritis.
  4. Paracrine effects: SVF cells secrete factors that exert paracrine effects, meaning they influence nearby cells. These paracrine factors can have anti-inflammatory effects and promote tissue regeneration, helping to combat the inflammatory causes of knee osteoarthritis. The resident cartilage forming cells produce cartilage matrix. Cartilage is the weight bearing cushioning material at the ends of bones. Regeneration of cartilage has been observed in this paper.

In PRS treatment, a small amount of adipose tissue is harvested from the patient and processed to extract SVF. The PRP is then combined with the SVF to create the PRS solution. This PRS solution is then injected into the area of injury or degeneration to promote tissue regeneration and repair.

If you wish to get this treatment for yourself, get in touch by filling the contact form in the home page.

 

 

PRS treatment knee arthritis India

PRS treatment knee Osteoarthritis India

Are you sick of seeing knee replacements fail among relatives and friends? So did this gentleman from Kolkata who was disillusioned with the hardships that his close relatives faced after a knee replacement. He decided to get a platelet-rich stroma ( PRS) treatment for his knee arthritis. Listen to his testimonial here. Many patients have benefited from PRS or SVF treatment in Chennai

What is PRS treatment?

Platelet-rich stroma (PRS) treatment in Chennai, India is a cutting-edge therapy for knee osteoarthritis (OA) that utilizes the patient’s own adipose (fat) tissue and PRP to promote healing and reduce pain. The treatment begins with a liposuction procedure to harvest adipose tissue from the patient’s thigh. The tissue is then processed to isolate stromal vascular fraction (SVF), which is a rich mixture of cells that include adipose-derived stem cells, endothelial cells, and other stromal cells. Once the SVF is prepared, it is mixed with platelet-rich plasma (PRP) to yield PRS, which is injected directly into the knee joint, where it can promote healing and repair of the damaged cartilage. The stem cells in the SVF can differentiate into various types of cells, including chondrocytes (cartilage cells), which can help to rebuild the damaged cartilage in the knee joint. Additionally, the SVF can stimulate the production of growth factors and other molecules that promote healing and reduce inflammation. PRP provides growth factors.

What is the result of PRS treatment

PRS treatment is a minimally invasive procedure that is performed on an outpatient basis. Patients typically experience minimal pain and discomfort during the procedure and can return to normal activities within a few days. The effects of the treatment can be seen within a few weeks and may continue to improve over time. Overall, PRS treatment for knee OA is a promising new therapy that utilizes the patient’s own cells to promote healing and reduce pain. It is a safe and effective option for patients who are seeking an alternative to traditional treatments such as surgery or medication. Platelet-rich stroma was injected into both knees of this gentleman for knee osteoarthritis, following which he has made a quick recovery.

SVF treatment knee arthritis Chennai India

SVF treatment knee arthritis Chennai India

Are you suffering from Knee osteoarthritis in Chennai India? If so, you may be wondering if there is an available alternative treatment to knee replacement that can help you. In this video, we will hear from this patient about the reason why she chose SVF treatment. She had seen the failure of knee replacements done elsewhere in other patients This treatment is available in Chennai India and can help you become pain-free!

What is SVF treatment?

Stromal vascular fraction treatment or SVF treatment knee arthritis Chennai India is a new treatment for knee arthritis. It avoids the risks associated with a knee replacement. It is done as a daycare procedure.

In this procedure, the surgeon removes fat from your body by liposuction and processes it in a centrifuge in the operating room. The processed fat contains a mixture of cells, vascular stroma, growth factors, and others. It is then mixed with PRP and then injected into the knee. The procedure takes about an hour for one knee. Patients are able to return home within a few hours. They may feel some discomfort on the first day but the pain will improve.

How is it better than bone marrow treatment?

SVF is derived from fat. It is superior to bone marrow. See this post to know more about the advantages of fat over bone marrow.

Is it better than knee replacement?

According to this lady, she had seen many failures of knee replacement done elsewhere. Other patients have also stated that a knee replacement procedure with its necessary physiotherapy is an ordeal.

What is the evidence for SVF treatment?

SVF treatment is a safe procedure with proven results. A double-blind study has confirmed the effectiveness of SVF therapy. There are other studies that vouch for fat stem cell treatment in knee osteoarthritis. My longest follow-up for stem cell treatment for knee arthritis is seven years. See this video 

In this video, this lady states that she had seen many successes of SVF treatment in India by Dr.A.K.Venkatachalam

PRP therapy knee arthritis Chennai

Platelet-rich plasma (PRP) treatment Chennai.

Platelet-rich plasma (PRP) treatment Chennai.

What are platelets?

Platelets are a type of cell in the blood primarily responsible for clotting. In addition to their paramount clotting function, they can also perform tissue repair as they also contain chemicals known as growth factors inside one of the three types of granules inside them which support healing and recovery processes. Platelets have three types of granules inside them known as α–granules, dense granules, and lysosomes. These granules are released when platelets encounter external tissues. Platelets swell and burst and release their granules.

What is Platelet-rich plasma?

Platelet-rich Plasma (PRP) is a filtrate of plasma rich in platelets. It contains plasma which is the liquid portion of blood and one of the three types of blood cells called platelets. In PRP, plasma contains significantly more platelets than their baseline value in blood, so the concentration of growth factors can be five to 10 times higher.

How is Platelet-rich plasma prepared for injection?

To create platelet-rich plasma, doctors take a blood sample from the patient and place it into a device called a centrifuge that rapidly spins the sample, separating out the other components of the blood from the platelets and concentrating them within the plasma. See how PRP is prepared in this video.

What is the basis for the actions of platelets?

Platelets are known to provide a diverse array of growth factors that can work independently or with other proteins and cells to improve the healing process. Although the use of PRP in the dermatology and maxillofacial fields dates to more than 50 years, the study and application of this treatment in joint conditions is recent and growing. As mentioned before, the biological rationale for the clinical use of PRP includes the local action of growth factors, the modification of the inflammatory response, and the effects on cell proliferation and differentiation.

Which are the principal areas of the musculoskeletal tissue in which PRP is being used?

Intraarticular platelet-rich plasma (PRP) injection has emerged as a promising treatment for knee osteoarthritis. Studies to date, including multiple randomized controlled trials, have shown that PRP is a safe and effective treatment option for knee osteoarthritis. Intra-articular PRP is similar in efficacy to hyaluronic acid and seems to be more effective than hyaluronic acid in younger, active patients with low-grade osteoarthritis. Treatment benefits wane after 6-9 months Intraarticular platelet-rich plasma injection in the treatment of knee osteoarthritis: review and recommendations – PubMed (nih.gov)

In addition, they are used to heal tendon, fascia, and ligament degenerative conditions and tears. They are also used to initiate the repair of peripheral nerves like the ulnar and median nerves when these are enlarged and compressed in the elbow and palm as in cubital tunnel and carpal tunnel syndromes.

PRP is also used to accelerate ACL repairs and meniscal repairs in the knee. PRP can be combined with the Stromal vascular fraction to yield platelet-rich stroma (PRS). This is used to treat knee Osteoarthritis, avascular necrosis, and cartilage lesions.

See how PRP injection alleviated this gentleman’s knee pain-

Platelet-rich plasma (PRP) treatment for knee cartilage lesions and osteoarthritis Chennai.

Listen to how a young man benefited from a PRP injection to his shoulder in this video

See how effective PRP was for treating heel pain in this video

If you wish to make an appointment e mail me at drvenkat@kneeindia.com or call the hospital number at +91 44 42938938.

Stem cell treatment knee osteoarthritis India

Stem cell treatment knee osteo-arthritis India

Stem cell treatment Knee osteoarthritis India. Listen to a West Bengal patient’s experience. Her ten-year-old suffering was relieved after fat stem cell treatment in Chennai. She felt immediate relief. She didn’t want a knee replacement at this stage as she was frightened of the pain during and after the procedure.

She was overjoyed that this procedure was rapidly and painlessly done. She felt pain relief the next day after the procedure. On current follow-up via a telephone conversation, her condition has greatly improved.

Orthobiologic treatment Chennai India,

Orthobiologic treatment Knee Osteoarthritis India, See the immediate result

Orthobiologic treatment Knee Osteoarthritis India, See the immediate result. A sixty-five-year-old gentleman regained his mobility and flexibility within one and half hours after Orthobiologic treatment of his chronic knee arthritis. In this video, he shows that he can jog and walk normally shortly after the treatment. He is delighted to have regained normalcy after the treatment.  He preferred this treatment over a knee replacement.

Stem cell treatment knee arthritis Chennai

Stem cell treatment knee arthritis Chennai

Stem cell treatment knee arthritis Chennai. See how stem cells are prepared in the operating theatre from your own tissues. This is a daycare procedure done under local anesthesia. It is recommended in middle-aged patients with knee arthritis and desirous of avoiding knee replacement. See more patient testimonials here

If your knee arthritis is advanced, then you might want to go here to seek a knee replacement in India